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Post Doc (m/f) Islet Biology

Responsibilities

As a member of our Islet Biology Research Team in the Diabetes Division in Frankfurt you will be part of an interdisciplinary team responsible in conducting experiments that are focusing on in vitro differentiation of human pluripotent stem cells (hPSC) into functional beta like cells to allow their reliable use for drug screening efforts. You will be assessing the efficiency of the in vitro differentiation using combination of transcriptomics / RNA SEQ, immunocytochemistry / FACS / High Content Imaging and functional assays (eg. GSIS).

Your task will be to establish

reporter constructs, transcription factor tools using genome editing systems (e.g.CRISPR / CAS9 modules) or other virally based strategies for guidance and monitoring differentiation and expansion of the hPSC into functional beta-cells

assay systems in stem cell derived beta-cells to monitor stress response and induced de-differentiation for future drug screening efforts

Requirements and Qualifications

PhD as cell biologist, biologist or molecular biologist required

Strong knowledge in the areas of molecular biology, stem cell biology, genetic engineering tools (CRISP/CAS9) and epigenetics are prerequisite

Good experimental experience with FACS, retro/lentiviral systems, RNA SEQ

Background in the area of metabolic disease and/or diabetes research

Strong track record of scientific achievement (publications in peer reviewed journals)

Excellent oral and written communication skills

Strong team player with analytical skills and interest to work in a highly interdisciplinary area

Fluent in English, knowledge of German is a plus

Terms of Employment

The position in the Stem Cell Lab of the Islet Biology Cluster is advertised for 1,5 years and will be based in Frankfurt, Germany.

Our offer

An international work environment, in which you can develop your talent and realize ideas and innovations within a competent team

An attractive, market-oriented salary aligned with your qualifications and including social benefits above average (e.g. company pension plans, health management)

An individual and well-structured introduction and training of new employees

As a globally successful and constantly growing company, Sanofi provides international career paths as well

Sanofi is a global healthcare leader focused on patients' needs, engaged in the research, development, manufacturing and marketing of therapeutic solutions focused on patients’ needs. Sanofi has core strengths in diabetes solutions, human vaccines, innovative drugs, consumer healthcare, emerging markets and Sanofi Genzyme.

At Sanofi, our ambition is to be an integrated global healthcare company, focused on patients’ needs. Much more than just a leading pharmaceutical company, Sanofi is committed to transforming scientific innovations into solutions and services that protect health, enhance life, and respond to the needs of the 7 billion people in the world. We trust our ambition to guide and inspire us as we work to create a future with optimal health and wellness for everyone.

If you are interested, please send us your online application.

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