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Job Title: Postdoctoral Training Fellow Closing Date of vacancy: 19 November 2016

pision: Molecular Pathology

Team: Systems and Precision Cancer Medicine

Type of Contract: Fixed Term 

Length of Contract: 1 year

Salary Range: £29,960 – £42,820 p.a. (full salary scale) Work Location: Sutton (Surrey) Hours per week: 35

The Institute of Cancer Research, London, is one of the world’s most influential cancer research institutes, with an outstanding record of achievement dating back more than 100 years. We provided the first convincing evidence that DNA damage is the basic cause of cancer, laying the foundation for the now universally accepted idea that cancer is a genetic disease. Today, The Institute of Cancer Research (ICR) leads the world at isolating cancer-related genes and discovering new targeted drugs for personalised cancer treatment. Under the leadership of our Chief Executive, Professor Paul Workman FMedSci, the ICR is ranked as the UK’s leading academic research centre. Together with our partner The Royal Marsden, we are rated in the top four cancer centres globally. The ICR is committed to attracting, developing and retaining the best minds in the world to join us in our mission – to make the discoveries that defeat cancer.

A Postdoctoral Training Fellow position is available to play a key role in facilitating the research of the Systems and Precision Cancer Medicine Team (Team Leader Anguraj Sadanandam). Our interdisciplinary lab focuses on personalized medicine and companion diagnostics using cancer subtypes and evolution by integrating multi-omics (molecular and metabolism) and phenomics (phenotypes) data. We perform this by integrating wet-lab science with computational biology skills by cross-comparing and integrating high-throughput data (including whole tumour and single cell omics data and cross-species analysis) between patients and in vivo and in vitro models. To this end, we have classified different tumor types including breast cancer cell lines, and pancreatic and colorectal tumours and cell lines into distinct molecular and/or drug response subtypes (PNAS 2012, Nature Medicine 2011, 2013 and 2015, and Cancer Discovery 2015). For more information please visit: http://www.icr.ac.uk/our-research/researchers-and-teams/dr-anguraj-sadanandam and http://www.icr.ac.uk/news-archive/scientists-uncover-four-different-types-of-bowel-cancer

You will help us in an immunoncology project characterizing tumours from in vivo models and performing pre-clinical trials. You will enjoy working in the interdisciplinary fields and collaborating with our internal and external collaborators. You will be a highly motivated and well-organised inpidual with a great attention to detail and strong analytical skills and will also have experience in in vivo (genetically engineered/xenograft) models performing pre-clinical trials in cancer. Your responsibilities will include day-to-day laboratory operations such as cell culture, different molecular biology and biochemical techniques (including, but not limited to DNA, RNA and protein isolation, isolation, RT-PCR, Western blots, immunohistochemistry, flow cytometry, FISH and metabolite analysis) and in vitro and in vivo experiments and interpretation of the results. In addition, you will work closely with the team and other collaborators to develop and validate hypothesis that will arise out of the high-throughput omics data including genomics and metabolomics.

The successful applicant will hold a PhD in biochemistry, molecular biology or any biological science. Experience in laboratory management, molecular biology and biochemical techniques, cell culture and in vivo experiments is essential as well as excellent organizational, scientific writing and communication skills. Experience in computational biology/bioinformatics would be advantageous.

This is an excellent opportunity for an independent and motivated inpidual to work in an exciting and highly collaborative environment. The position is offered on a fixed term 1 year contract. The full salary scale for this post is in the range from £29,960 to £42,820 p.a. inclusive. Starting salary will be based on previous postdoctoral experience. The position will be based in Sutton.

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