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Postdoctoral fellow in Computational studies of non-coding alterations in cancer : Gothenburg, Sweden

The Institute of Biomedicine is involved in both research and education. In both of these areas, we focus on fundamental knowledge of the living cell – what it consists of, how it works, how its function is directed by the genetic material, and how it interacts with various kinds of micro-organisms. Using this knowledge, we try to elucidate the causes of diseases, and find new ways to diagnose and treat them.

The Institute is composed of the following five departments:

• The Department of Infectious Diseases

• The Department of Microbiology and Immunology

• The Department of Pathology and Genetics

• The Department of Clinical Chemistry and Transfusion

Medicine

• The Department of Medical Biochemistry and Cell Biology

At present, the institute has about 350 employees and approximately 290 million SEK in total assets.

Subject area

Computational studies of non-coding alterations in cancer

Specific subject description

Tumor development involves somatic alterations in cellular DNA, typically in protein-coding cancer driver genes. However, there are also indications that changes in non-coding genomic DNA could be important. The aim of this project is to improve our understanding of how mutations and other alterations in non-coding genomic regions may contribute to tumorigenesis.

Job assignments

The project will involve bioinformatical analysis and integration of large-scale genomic data from tumors, including relevant public datasets. The emphasis will be on biological questions rather than bioinformatics methods. The work will be carried out in collaboration with experimental scientists. Relevant recent publications from our group include: Stewart et al., Plos Genetics 2015; Fredriksson et al., Nature Genetics 2014; Tang K-W et al., Nature Communications 2013; Akrami et al., PLoS One 2013; Jeggari A et al., Bioinformatics 2012.

Eligibility

An achieved doctoral degree is compulsory for a position as postdoctor at Göteborg University. The doctoral thesis shall be in a relevant area according to the specific position stated here. Since a position as postdoctor aims to give new holders of the doctorate the opportunity mainly to strengthen and develop their scholarly proficiency, we aim for those who have a doctoral degree not older than 3 years counting from last date of application.

The qualifications for academic positions are given in Chapter 4, Section 3 – 4 of the Higher Education Ordinance.

Assessment

Programming skills and linux/unix experience is a requirement, and knowledge of Matlab or R is desired. Previous experience with next-generation sequencing is recommended. Experience from relevant biological fields is desirable, and the applicant is expected to have published several articles in peer-reviewed journals. Excellent communicative skills are required, including fluency in oral and written English.

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