英国牛津大学2025年博士后招聘（结构生物学方向）

Postdoctoral Research Assistant in Structural Biology

University of Oxford- Sir William Dunn School of Pathology

Location:Oxford

Salary:£38,674 to £46,913 p.a.

Hours:Full Time

Contract Type:Fixed-Term/Contract

Placed On:28th April 2025

Closes:30th May 2025

Job Ref:179480

This is an exciting opportunity for an enthusiastic and self-motivated scientist to join the lab of Dr Katerina Toropova. The project aims to elucidate the molecular mechanisms of dynein-2 transport in cilia.

Transport within cilia, the cell’s signalling and sensory antennae, is central to human biology. It enables these cell-surface organelles to assemble and dynamically change their proteome in response to stimuli, allowing them to transduce signals to the cell interior. Dynein-2 lies at the heart of these processes, as it is the molecular motor responsible for all retrograde transport from the tip of cilia to the cell body. Its mutation causes severe developmental and degenerative conditions. Despite its central role, how dynein-2 utilizes the energy from ATP hydrolysis to power retrograde transport remains poorly understood. It is also unclear how the conformational landscape of dynein-2 is affected by diseases mutations.

This project involves using a multi-scale structural biology approach, involving cryo-EM, cryo-ET, FIB milling, and biochemical methods to understand mechanisms of dynein-2 transport, building on recent advances in the group (NSMB 2017 PMID 28394326; NSMB 2019 PMID: 31451806; Cell 2022, PMID: 36462505). The research will be conducted in a friendly and supportive atmosphere with access to outstanding facilities and within a vibrant postdoc community.

The applicant should hold, or be close to completion of, a PhD/DPhil in Structural Biology, Biochemistry, or Molecular/Cell Biology. Experience in protein expression and purification are required for this position. Experience in cryo-EM, cryo-ET, or FIB milling would be an advantage, but is not essential as training can be provided.

The post-holder will be responsible for managing their own academic research, establishing and optimising protocols, designing and accurately executing experiments, and contributing conceptually to the overall research programme. Good organisational and communication skills and the ability to work as part of a team are essential.

This is a full-time position available for 3 years in the first instance, with a possibility of extension. If you are interested in this role, and have the skills and experience we are looking for, please apply online. You will be required to upload a CV and supporting statement as part of your online application. The supporting statement should describe how you fit the criteria for the role, including your motivation and curiosity about the research project.

Informal enquiries about this post can be addressed to Dr Katerina Toropova: katerina.toropova@path.ox.ac.uk .

The closing date for applications is 12.00 midday on the 30 May 2025. Interviews will be held as soon as possible thereafter.

At the Dunn School we are committed to supporting the professional and career development of our postdocs and research staff. To help them thrive and achieve their ambitions, we have created a comprehensive range of opportunities and initiatives designed to provide an exceptional launchpad for their future careers

更多最新博士后招聘信息请关注博士后招聘网微信公众号（ID：boshihoujob）

祝君：学业有成，学成归来。

请您在邮件申请时在标题注明信息来自：博士后招聘网-boshihoujob.com，电话咨询时说明从博士后招聘网(www.boshihoujob.com)看到的博士后招聘信息。

声明：凡本网注明“来源：XXX”的文/图等稿件，本网转载出于传递更多信息及方便产业探讨之目的，并不意味着本站赞同其观点或证实其内容的真实性，文章内容仅供参考。如其他媒体、网站或个人从本网站转载使用，须保留本网站注明的“来源”，并自负版权等法律责任。作者如果不希望被转载或者联系转载等事宜，请与我们联系。邮箱：boshihoujob@163.com。