美国希望之城2023年招聘博士后职位（免疫肿瘤学、疫苗学和免疫学）

希望之城国家医疗中心(City of Hope NationalMedical Center)是一所顶尖的美国非盈利研究和治疗中心，专注于癌症、糖尿病和其他危及生命的疾病。

Postdoctoral Fellow - Immune-oncology, Vaccinology and Immunology

City of Hope

Position Summary

A Postdoctoral Fellowship opportunity is immediately available for a highly motivated individual in the laboratory of Dr. Larry Kwak, at the Beckman Research Institute of City of Hope, a prestigious NCI-designated Comprehensive Cancer Center.

Candidate Project Specifications

· He/she will study pre-clinical study for a personalized mRNA cancer vaccine against lymphoma.

· Using single-cell RNA analysis, he/she will study cell-intrinsic characteristics of BAFF-R CAR-T correlated with responses that can be used as markers of clinical outcomes.

Skills that are used in the lab include:

· Experience working with mice.

· Mammalian cell culture.

· Primary human cell (BM and PBMC) culture and handling.

· Multi-color FLOW cytometry.

· ELISA

· Cell-Sorting.

· Co-Culture Functional Assays.

· Familiar with novel single-cell RNA sequencing technologies and analysis pipelines.

Basic education, experience, and skills required for consideration:

· Ph.D. degree with research experience; a track record of publications in peer-reviewed scientific journals.

· Strong background in immune-oncology, vaccinology and/or immunology.

· Expertise in multi-parameter FLOW cytometry.

· Expertise in cell-based assays (e.g. co-culture functional assays, multi-color flow cytometry, ELISA, cell sorting, etc.)

· Experience executing primary immune cell assays and mechanism of action studies (T cell isolation, expansion, cytokine secretion assays, T cell differentiation, T cell killing assay etc).

· Excellent communication skills with the ability to work independently and as part of a team.

· Highly motivated and self-directed applicants interested in translational research in cancer immunotherapy are strongly encouraged to apply. However, applicants with related training and experience will be given priority.

Additional Information:

As a condition of employment, City of Hope requires staff to comply with all state and federal vaccination mandates.

For more scientific background, please refer to our publications:

o Science 2002 Nov 1; 298(5595):1025-9: https://doi.org/10.1126/science.1075565

o Nature Medicine 2005 Sep; 11(9): 986-91: https://doi.org/10.1038/nm1290

o BMC Cancer 2018 Feb 13;18(1): https://doi.org/10.1186/s12885-018-4094-2

o Sci Transl Med 2019 Sep 25. https://doi.org/10.1126/scitranslmed.aaw9414

o Blood volume 136, Supplement 1 2020 Nov https://doi.org/10.1182/blood-2020-140007

o Blood 2022 Mar 3 https://doi.org/10.1182/blood.2020008493

Salary / Pay Rate Information:

Pay Rate: $31.00 - $34.23 / hour

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